Table 1.

Stages of the kinases insensitivity under disease conditions

Stage	Model system	PI3K activity	Akt activity	GSK3 activity	Insensitive kinase	Phenotype
0	Male Sprague Dawley (SD) Rats	High	High	Low	None	Early insulin resistance
1	Human retinal pigment epithelial cells (HRPE) treated with VEGF	High	High	High	GSK3	Low growth
2	Human monocytes overexpressing IL17RC or treated with VEGF	High	Unchanged or low	High	GSK3, Akt	Low growth
3	HRPE overexpressing IL17RC	Low	Low	High	GSK3, Akt, PI3K	Low growth