Fig. 2.

Blood glucose level

Blood glucose increased greatly 3 days after intraperitioneal injection of STZ and decreased after treatment in Groups HDL, HDM and HDH. C: normal control group, standard rat diet for 14 weeks and treated with 0.9% saline 10 mL/kg every day (n = 10); H: high-fat diet + STZ group, high-fat diet for 14 weeks and treated with 0.9% saline 10 mL/kg every day (n = 15 at 0 and 6 weeks and n = 10 at 6 weeks + 3 days, 8 weeks, 10 weeks, 12weeks and 14 weeks; HS: high-fat diet + STZ with simvastatin treated group, high-fat diet for 14 weeks and treated with simvastatin 0.9 mg/10 mL/kg every day (n = 15 at 0 and 6 weeks and n = 10 at 6 weeks + 3 days, 8 weeks, 10 weeks, 12weeks and 14 weeks); HDL: high-fat diet + STZ with low dose of DSKT treated group, high-fat diet for 14 weeks and treated with DSKT 3.75 g/10 mL/kg every day (n = 15 at 0 and 6 weeks and n = 10 at 6 weeks + 3 days, 8 weeks, 10 weeks, 12weeks and 14 weeks); HDM: high-fat diet + STZ with medial dose of DSKT treated group, high-fat diet for 14 weeks and treated with DSKT 7.5 g/10 mL/kg every day (n = 15 at 0 and 6 weeks and n = 10 at 6 weeks + 3 days, 8 weeks, 10 weeks, 12weeks and 14 weeks); HDH: high-fat diet + STZ with high dose of DSKT treated group, high-fat diet for 14 weeks and treated with DSKT 15 g/10 mL/kg every day (n = 15 at 0 and 6 weeks and n = 10 at 6 weeks + 3 days, 8 weeks, 10 weeks, 12weeks and 14 weeks). 0W, 0 week; 2W, 2 weeks; 4W, 4weeks; 6W, 6weeks; 8W, 8 weeks; 10W, 10 weeks; 12W, 12 weeks; 14W, 14 weeks. 6 weeks + 3 days means 3 days after intraperitioneal injection of STZ. DSKT, daisaikoto; STZ, streptozotocin.