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. 2016 Aug 4;16:597. doi: 10.1186/s12885-016-2644-z

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Immunohistochemical detection of fibrillin-1 (FBN-1) and OCT3/4 expression in testicular tissues. a Germ cell neoplasia in situ (GCNIS), showed constant and strong cytoplasmic granular FBN-1 positivity (brown colour) with negativity in normal seminiferous tubules with spermiogenesis; (b) OCT3/4 expression in the same sample as in (a) with strong nuclear positivity in GCNIS (brown colour) and negativity in normal tubules. c Seminoma with focal strong cytoplasmic FBN-1 positivity; (d) Embryonal carcinoma with focal moderate to strong cytoplasmic FBN-1 positivity; (e) Yolk sac tumour with focal strong cytoplasmic FBN-1 positivity. Original magnification ×40/×400