Table 1.

Hemodynamics and echocardiography data at 28 day after MCT injection

Parameters	Sham	Vehicle	−2w-MCT	−2w-shRNA	2w-MCT	2w-shRNA
No. of surviving rats	20	19	18	18	17	16
Body weight, g	360 ± 8	296 ± 5*	291 ± 6*	335 ± 7*,**	286 ± 7*	323 ± 6*,**
Heart Rate, bpm	418 ± 12	420 ± 16	425 ± 14	422 ± 15	428 ± 16	426 ± 15
Cardiac Output (ml/min)	134 ± 2.3	107 ± 4*	107 ± 4*	116 ± 3.4*	109 ± 4.2*	112 ± 2.8*
Ejection Fraction (%)	66.8 ± 4.2	48.7 ± 4.6*	46.8 ± 3.9*	67.2 ± 5.3**	47.6 ± 4.3*	64.5 ± 3.4**
Pulmonary artery , cm	0.295 ± 0.01	0.41 ± 0.025*	0.38 ± 0.03*	0.317 ± 0.03**	0.42 ± 0.04*	0.336 ± 0.02**
Mean blood pressure	92.5 ± 3.2	88.5 ± 4.7	89.6 ± 3	90.8 ± 2.5	87.4 ± 3.2	88.3 ± 3.6
RV/BW (mg/g)	3.7 ± 0.2	10 ± 0.9*	9.7 ± 1*	5.6 ± 0.8*,**	9.4 ± 0.9*	6.2 ± 0.7*,**
RV wall thickness, cm	0.12 ± 0.01	0.21 ± 0.03*	0.21 ± 0.04*	0.13 ± 0.03**	0.22 ± 0.03*	0.16 ± 0.02**
RV area, mm2	11.7 ± 0.3	22 ± 0.7*	21.5 ± 0.6*	12.5 ± 0.5**	21 ± 0.4*	14.6 ± 0.4*,**
LV area, mm2	22.1 ± 0.4	22.5 ± 0.5	22.4 ± 0.4	22.3 ± 0.7	22.6 ± 0.5	22.4 ± 0.6

RV right ventricle, LV left ventricle, BW body weight. All values are mean ± SD

*p <0.05 compared with sham group

**p < 0.05 compared with respective control MCT group