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. 2016 Aug 3;9:77. doi: 10.1186/s13041-016-0254-y

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — DPAT-induced hypothermia in Deaf1 knockout mice. a, b Early generation (<2) male Deaf1-/- mice show enhanced DPAT-induced hypothermia. Average body temperature change over time for male a or female b Deaf1 wild-type (WT) and Deaf1 knockout (KO) on C57BL/6-BALB/c background following 0.9 % saline or 0.5 mg/kg 8-OH-DPAT (DPAT) injection. *p < 0.05; **p < 0.01; ***p < 0.001 vs. wild-type. c, d Reduced DPAT-induced hypothermia in late generation (≥3) Deaf1-/- male mice. Data are presented as mean ± SE; *p < 0.05; ***p < 0.001 vs. wild-type