Table 2.
Plasma biomarkers of liver damage in dogs, at the initiation (Week -1) and the end (Week 24) of a 24-wk period of consumption of PEGB at 4, 20 or 40 mg/kg/d. (Data are means ± SEM, n = 6/group; minima and maxima values are mentioned in parenthesis)
| Biomarkers (reference values) | Units | Control | PEGB | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 4 mg/kg/d | 20 mg/kg/j | 40 mg/kg/j | |||||||
| Week -1 | Week 24 | Week -1 | Week 24 | Week -1 | Week 24 | Week -1 | Week 24 | ||
| Alanine transaminase (10–118) | U/L | 38 ± 5 (27–59) | 36 ± 5 (26–57) | 51 ± 7 (26–60) | 44 ± 9 (20–76) | 45 ± 2 (39–52) | 46 ± 39 (38–61) | 41 ± 5 (28–60) | 45 ± 4 (28–60) |
| Alkaline phosphate (20–150) | U/L | 59 ± 9 (33–88) | 63 ± 10 (32–86) | 63 ± 6 (49–86) | 65 ± 12 (51–126) | 55 ± 9 (37–88) | 57 ± 14 (33–109) | 48 ± 7 (29–78) | 49 ± 9 (20–80) |