Table 1.
Correlation of DEF6, p53 and p16 expression in histological subtypes of ovarian carcinoma
| Histology subtypes of ovarian carcinoma | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Serous carcinoma (N = 75) | Mucinous carcinoma (N = 36) | Endometrioid carcinoma (N = 28) | Clear cell carcinoma (N = 41) | |||||||
| Antibody | Score | No. | (%) | No. | (%) | No. | (%) | No. | (%) | P-value |
| DEF6 | 0 | 8 | (10.7) | 8 | (22.2) | 2 | (7.1) | 6 | (14.6) | <0.001* |
| 1 | 7 | (9.3) | 12 | (33.3) | 4 | (14.3) | 15 | (36.6) | ||
| 2 | 21 | (28.0) | 9 | (25.0) | 4 | (14.3) | 11 | (26.8) | ||
| 3 | 39 | (52.0) | 7 | (19.4) | 18 | (64.3) | 9 | (22.0) | ||
| NA | 0 | (0.0) | 0 | (0.0) | 0 | (0.0) | 0 | (0.0) | ||
| p53 | 0 | 26 | (34.7) | 12 | (33.3) | 6 | (21.4) | 6 | (14.6) | <0.001* |
| 1 | 11 | (14.7) | 17 | (47.2) | 18 | (64.3) | 29 | (70.7) | ||
| 2 | 1 | (1.3) | 2 | (5.6) | 1 | (3.6) | 2 | (4.9) | ||
| 3 | 36 | (48.0) | 5 | (13.9) | 3 | (10.7) | 4 | (9.8) | ||
| NA | 1 | (1.3) | 0 | (0.0) | 0 | (0.0) | 0 | (0.0) | ||
| p16 | 0 | 12 | (16.0) | 29 | (80.6) | 11 | (39.3) | 14 | (34.1) | <0.001* |
| 1 | 6 | (8.0) | 3 | (8.3) | 6 | (21.4) | 16 | (39.0) | ||
| 2 | 0 | (0.0) | 0 | (0.0) | 0 | (0.0) | 0 | (0.0) | ||
| 3 | 56 | (74.7) | 3 | (8.3) | 11 | (39.3) | 10 | (24.4) | ||
| NA | 1 | (1.3) | 1 | (2.8) | 0 | (0.0) | 1 | (2.4) | ||
NA, Not applicable (not enough material for analysis or technical limitations)
P- value Fisher’s exact or Chi-square test analysis (*significant difference)