Table 2.
Overall survival (OS) and disease-free survival (DFS) according to DEF6/p16 and DEF6/p53 co-expressions
| OS (SE) | 95 % CI | Median (SE) (95 % CI) | P-value | DFS (SE) | 95 % CI | Median (SE) (95 % CI) | P-value | |
|---|---|---|---|---|---|---|---|---|
| DEF6/p16 co-expression | ||||||||
| DEF6-negative/ p16-negative |
75 (11) | 53–98 | 90 (30) 30–149 |
0.027* | 75 (11) | 52–98 | 90 (30) 30–149 |
0.023* |
| DEF6-negative/ p16-positive |
54 (16) | 22–86 | 48 (30) 0–107 |
54 (16) | 22–86 | 48 (30) 0–107 |
||
| DEF6-postive/ p16-negative |
41 (10) | 22–61 | 27 (10) 6–47 |
39 (9) | 19–58 | 27 (9) 8–45 |
||
| DEF6-positive/ p16-positive |
32 (6) | 19–45 | 21 (4) 12–30 |
32 (6) | 19–44 | 19 (3) 12–25 |
||
| DEF6/p53 co-expression | ||||||||
| DEF6-negative /p53 (scores 1 and 2) |
73 (10) | 52-93 | 72 (20) 31-113 |
0.031* | 73 (10) | 52-93 | 72 (20) 31-113 |
0.028* |
| DEF6-negative /p53 (scores 0 and 3) |
64 (17) | 30–99 | 76 (79) 0–230 |
64 (17) | 30–97 | 76 (79) 0–230 |
||
| DEF6-postive /p53 (scores 1 and 2) |
48 (11) | 26–70 | 48 (25) 0–97 |
44 (10) | 22–65 | 31 (16) 0–62 |
||
| DEF6-positive /p53 (scores 0 and 3) |
29 (6) | 16–41 | 19 (2) 13–24 |
28 (6) | 16–41 | 17 (1) 14–19 |
SE, Standard error; CI, confidence interval
*significant difference
Log-rank test
DEF6 positive: Scores 2 and 3; DEF6 negative: Scores 0 and 1
p16 positive: Scores 2 and 3; p16 negative: Scores 0 and 1