Table 2. Significantly enriched pathways (downstream genes of PLOD2).
| KEGG pathway entry number | Annotation | Number of genes | P-value | Genes | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4010 | MAPK signalling pathway | 16 | 8.14E−04 | IL1B | GADD45A | FGF2 | DDIT3 | FLNA | IL1A | DUSP6 | DUSP5 | MECOM |
| CASP3 | KRAS | RPS6KA3 | ARRB1 | GADD45B | PAK2 | DUSP22 | ||||||
| 5200 | Pathways in cancer | 14 | 1.56E−02 | CYCS | FGF2 | ITGA6 | ITGA3 | TPM3 | TCEB1 | LAMC1 | MECOM | CASP3 |
| WNT5B | KRAS | RALA | TRAF1 | CBLB | ||||||||
| 4141 | Protein processing in endoplasmic reticulum | 14 | 8.33E−05 | UBE2J1 | HYOU1 | HSPA5 | DNAJA2 | DNAJB11 | DDIT3 | UBE2E1 | DNAJC1 | SEC24A |
| DERL2 | MAN1A2 | CAPN2 | HERPUD1 | PDIA4 | ||||||||
| 4144 | Endocytosis | 9 | 3.67E−02 | ITCH | CAV1 | PIP5KL1 | RAB31 | SMAP2 | ARRB1 | EPS15 | ERBB3 | CBLB |
| 5152 | Tuberculosis | 9 | 2.53E−02 | IL1B | CYCS | RIPK2 | CREB1 | IL1A | CASP3 | CEBPG | CORO1A | HLA-DMB |
| 4120 | Ubiquitin-mediated proteolysis | 9 | 7.81E−03 | CDC26 | UBE2J1 | PRPF19 | CDC20 | ITCH | UBE2E1 | TCEB1 | ERCC8 | CBLB |
| 4910 | Insulin signalling pathway | 9 | 7.78E−03 | EXOC7 | HK2 | RPS6KB1 | RHEB | HKDC1 | KRAS | PPP1R3C | PYGL | CBLB |
| 5010 | Alzheimer's disease | 8 | 4.15E−02 | IL1B | CYCS | APH1A | CAPN2 | NDUFB3 | PLCB3 | CASP3 | COX7A2L | |
| 5323 | Rheumatoid arthritis | 8 | 1.75E−03 | IL1B | ATP6V1C1 | ATP6V1A | CCL20 | IL1A | CSF1 | CCL5 | HLA-DMB | |
| 3008 | Ribosome biogenesis in eukaryotes | 8 | 8.44E−04 | UTP18 | NOL6 | NOP56 | NXT1 | DKC1 | WDR43 | UTP14A | RPP40 | |
| 4115 | p53 signalling pathway | 8 | 6.70E−04 | CYCS | GADD45A | SESN2 | CASP3 | STEAP3 | CCNG1 | GADD45B | PMAIP1 | |
| 4110 | Cell cycle | 7 | 3.68E−02 | CDC26 | GADD45A | CDC20 | CDC25C | MAD2L1 | ORC1 | GADD45B | ||
| 4012 | ErbB signalling pathway | 7 | 9.20E−03 | NRG1 | RPS6KB1 | NRG2 | KRAS | PAK2 | ERBB3 | CBLB | ||
| 4640 | Haematopoietic cell lineage | 7 | 7.55E−03 | IL1B | ITGA6 | ITGA3 | IL1A | CSF1 | CD9 | IL7 | ||
| 520 | Amino sugar and nucleotide sugar metabolism | 7 | 8.07E−04 | HK2 | UAP1 | UGDH | GNPNAT1 | GNPDA1 | HKDC1 | GFPT1 | ||
| 970 | Aminoacyl-tRNA biosynthesis | 6 | 1.23E−03 | IARS | FBXO17 | GARS | MTFMT | YARS | SARS | |||
| 5020 | Prion diseases | 6 | 6.56E−04 | IL1B | HSPA5 | IL1A | LAMC1 | PRNP | CCL5 | |||
| 5120 | Epithelial cell signaling in Helicobacter pylori infection | 5 | 3.82E−02 | JAM2 | ATP6V1C1 | ATP6V1A | CASP3 | CCL5 | ||||
| 3018 | RNA degradation | 5 | 3.74E−02 | DCPS | PAN3 | ENO3 | CNOT6 | LSM5 | ||||
| 5416 | Viral myocarditis | 5 | 3.35E−02 | CYCS | CAV1 | CASP3 | EIF4G2 | HLA-DMB | ||||
| 10 | Glycolysis/gluconeogenesis | 5 | 3.29E−02 | HK2 | ENO3 | HKDC1 | PGAM1 | PGAM4 | ||||
| 4150 | mTOR signalling pathway | 5 | 2.01E−02 | RPS6KB1 | RHEB | EIF4B | CAB39L | RPS6KA3 | ||||
| 500 | Starch and sucrose metabolism | 5 | 1.98E−02 | HK2 | ENPP1 | UGDH | HKDC1 | PYGL | ||||
| 4130 | SNARE interactions in vesicular transport | 4 | 2.60E−02 | VAMP1 | VAMP4 | STX3 | BET1 | |||||
| 260 | Glycine, serine and threonine metabolism | 4 | 2.09E−02 | CTH | PHGDH | PSAT1 | PSPH | |||||
| 910 | Nitrogen metabolism | 3 | 4.18E−02 | ASNS | CTH | CA13 | ||||||
| 524 | Butirosin and neomycin biosynthesis | 2 | 2.52E−02 | HK2 | HKDC1 | |||||||
Abbreviations: KEGG=Kyoto Encyclopedia of Genes and Genomes; MAPK=mitogen-activated protein kinase; mTOR=mammalian target of rapamycin; PLOD2=procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2; SNARE=soluble N-ethylmaleimide-sensitive factor attached protein receptor.