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. 2016 Jun 23;115(3):346–353. doi: 10.1038/bjc.2016.182

Table 1. Baseline population characteristics.

  Wild type (n=258) mKRAS (n=196) mEGFR (n=27) P-value
Gender        
 Male 171 (66%) 132 (67%) 12 (44%) 0.06
 Female 87 (34%) 64 (33%) 15 (56%)  
Mean agea 63.8±11.25 64.4±11.28 64.7±13.56 0.93
Charlson comorbidity index        
 0 32 (13%) 18 (9%) 3 (11%) 0.69
 1 94 (36%) 74 (38%) 13 (48%)  
 2 67 (26%) 58 (29%) 4 (15%)  
 3 65 (25%) 46 (23%) 7 (26%)  
pT        
 1 61 (24%) 42 (22%) 4 (15%)  
 2 104 (41%) 101 (51%) 6 (22%) 0.004
 3 77 (30%) 44 (23%) 16 (53%)  
 4 16 (6%) 9 (5%) 1 (4%)  
pN        
 N+ 94 (37%) 164 (84%) 15 (56%) <0.0001
 N0 164 (63%) 32 (16%) 12 (44%)  
Angio-invasion        
 Yes 75 (29%) 121 (62%) 11 (41%) <0.0001
 No 183 (71%) 75 (38%) 16 (59%)  
Smoking habit        
 Never smoked 23 (9%) 22 (11%) 23 (85%) <0.0001
 Former smoker 115 (44%) 80 (41%) 3 (11%)  
 Active smoker 120 (47%) 94 (48%) 1 (4%)  
Neo-adjuvant treatment        
 Yes 107 (41%) 62 (32%) 17 (63%) 0.003
 No 151 (59%) 134 (68%) 10 (37%)  
Type of neo-adjuvant treatment        
 Chemotherapy 76 (72%) 54 (85%) 9 (53%) <0.0001
 Radio-chemotherapy 30 (28%) 9 (15%) 8 (47%)  
Adjuvant treatment        
 Yes 98 (38%) 165 (84%) 16 (59%) <0.0001
 No 160 (62%) 31 (16%) 11 (41%)  
Type of adjuvant treatment        
 Chemotherapy 74 (76%) 151 (91%) 15 (94%) <0.0001
 Radiotherapy 4 (4%) 1 (1%) 1 (6%)  
 Radio-chemotherapy 20 (20%) 13 (8%) 0  
Lymph node ratio        
 <1/3 86 (91%) 76 (47%) 11 (73%) <0.0001
 ⩾1/3 8 (9%) 88 (53%) 4 (27%)  
Skip-N2        
 Yes 0 4 (13%) 3 (50%) 0.07
 No 0 27 (87%) 3 (50%)  
Microscopic N        
 Yes 0 15 (9%) 8 (53%) <0.0001
 No 94 (100%) 149 (91%) 7 (47%)  
Number of N2 stations        
 1 42 (79%) 20 (65%) 6 (100%) 0.11
 2 11 (21%) 11 (35%) 0  
Resection margins        
 R0 252 (98%) 192 (99%) 26 (96%) 0.47
 R1 6 (2%) 2 (1%) 1 (4%)  

Abbreviations: mEGFR=epidermal growth factor receptor mutations; mKRAS=V-Ki-ras2 Kirsten rat sarcoma viral oncogene homologue mutations.

a

Data are given as mean±s.d. Bold values were used to indicate significant variables.