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. 2016 Jun 23;115(3):346–353. doi: 10.1038/bjc.2016.182

Table 2. Baseline population characteristics according to KRAS amino acid substitution.

  KRAS G12C (n=91) KRAS G12V (n=85) Other KRAS mutations (n=20) P-value
Gender        
 Male 59 (65%) 60 (71%) 13 (65%) 0.7
 Female 32 (35%) 25 (29%) 7 (35%)  
Mean agea 64.4±11.27 63±9.1 63.5±9.16 0.68
Charlson comorbidity index        
 0 6 (7%) 9 (11%) 4 (20%) 0.17
 1 39 (43%) 27 (32%) 8 (40%)  
 2 30 (33%) 23 (27%) 4 (20%)  
 3 16 (17%) 26 (30%) 4 (20%)  
pT        
 1 9 (10%) 27 (32%) 7 (32%) <0.0001
 2 63 (69%) 26 (31%) 11 (55%)  
 3 15 (17%) 27 (32%) 2 (10%)  
 4 4 (4%) 5 (5%) 0  
pN        
 N+ 65 (71%) 83 (98%) 15 (75%) <0.0001
 N0 26 (29%) 2 (2%) 15 (25%)  
Angio-invasion        
 Yes 24 (26%) 84 (99%) 12 (60%) <0.0001
 No 67 (74%) 1 (1%) 18 (4%)  
Smoking habit        
 Never smoked 9 (10%) 9 (11%) 4 (20%) 0.33
 Former smoker 33 (36%) 37 (44%) 10 (50%)  
 Active smoker 49 (54%) 39 (45%) 6 (30%)  
Neo-adjuvant treatment        
 Yes 26 (29%) 32 (38%) 4 (20%) 0.22
 No 65 (71%) 53 (62%) 16 (80%)  
Type of neo-adjuvant treatment        
 Chemotherapy 22 (85%) 28 (88%) 3 (75%) 0.49
 Radio-chemotherapy 4 (15%) 4 (12%) 1 (25%)  
Adjuvant treatment        
 Yes 66 (73%) 83 (98%) 15 (75%) <0.0001
 No 25 (27%) 2 (2%) 5 (25%)  
Type of adjuvant treatment        
 Chemotherapy 55 (83%) 81 (98%) 14 (93%) <0.0001
 Radiotherapy 1 (2%) 0 0  
 Radio-chemotherapy 10 (15%) 2 (2%) 1 (7%)  
Lymph node ratio        
 <1/3 59 (91%) 7 (8%) 10 (67%) <0.0001
 ⩾1/3 6 (9%) 76 (92%) 5 (33%)  
Skip-N2        
 Yes 2 (8%) 0 2 (50%) 0.06
 No 24 (92%) 1 (100%) 2 (50%)  
Microscopic N        
 Yes 8 (12%) 5 (6%) 2 (13%) 0.36
 No 57 (88%) 78 (94%) 13 (87%)  
Number of N2 stations        
 1 17 (65%) 0 3 (75%) 0.36
 2 9 (35%) 1 (100%) 1 (25%)  
Resection margins        
 R0 90 (99%) 84 (99%) 20 (100%) 0.89
 R1 1 (1%) 1 (1%) 0  

Abbreviation: KRAS=V-Ki-ras2 Kirsten rat sarcoma viral oncogene homologue.

a

Data are given as mean +/− standard deviation. Bold values were used to indicate significant variables.