Table 4. Site of recurrence according to variables included in univariate analysis.
| Bone | Liver | Brain | PP | Lung | Adrenal glands | P-value | |
|---|---|---|---|---|---|---|---|
|
Gender | |||||||
| Male | 78 (66%) | 38 (68%) | 27 (53%) | 86 (67%) | 74 (66%) | 12 (75%) | 0.48 |
| Female | 40 (34%) | 18 (32%) | 24 (47%) | 42 (33%) | 38 (34%) | 4 (25%) | |
|
LNI | |||||||
| Yes | 57 (48%) | 29 (52%) | 26 (51%) | 100 (78%) | 50 (45%) | 11 (69%) | <0.0001 |
| No | 61 (52%) | 27 (48%) | 25 (49%) | 28 (22%) | 62 (55%) | 5 (31%) | |
|
Angio-invasion | |||||||
| Yes | 30 (25%) | 16 (29%) | 16 (31%) | 97 (76%) | 40 (36%) | 8 (50%) | <0.0001 |
| No | 88 (75%) | 40 (71%) | 35 (69%) | 31 (24%) | 72 (64%) | 8 (50%) | |
|
Neo-adjuvant treatment | |||||||
| Yes | 39 (33%) | 27 (48%) | 15 (30%) | 55 (43%) | 45 (40%) | 5 (31%) | 0.22 |
| No | 79 (67%) | 29 (52%) | 36 (70%) | 73 (57%) | 67 (60%) | 11 (69%) | |
|
Adjuvant treatment | |||||||
| Yes | 59 (50%) | 30 (53%) | 26 (51%) | 101 (79%) | 52 (46%) | 11 (69%) | <0.0001 |
| No | 59 (50%) | 26 (47%) | 25 (49%) | 27 (21%) | 60 (54%) | 5 (31%) | |
|
LNR ⩾1/3 | |||||||
| Yes | 5 (9%) | 6 (21%) | 7 (27%) | 75 (75%) | 6 (12%) | 1 (10) | <0.0001 |
| No | 52 (91%) | 23 (79%) | 19 (73%) | 25 (25%) | 44 (88%) | 9 (91%) | |
|
Skip-N2 | |||||||
| Yes | 2 (11%) | 1 (50%) | 2 (40%) | 0 | 0 | 2 (100%) | 0.01 |
| No | 16 (89%) | 1 (50%) | 3 (60%) | 5 (100%) | 5 (100%) | 0 | |
|
Microscopic N | |||||||
| Yes | 6 (11%) | 2 (7%) | 7 (27%) | 6 (6%) | 2 (4%) | 0 | 0.01 |
| No | 51 (89%) | 27 (93%) | 19 (73%) | 94 (94%) | 48 (96%) | 11 (100%) | |
|
Resection margins | |||||||
| R0 resection | 115 (98%) | 55 (98%) | 51 (100%) | 126 (98%) | 109 (97%) | 16 (100) | 0.84 |
| R1 resection | 3 (2%) | 1 (2%) | 0 | 2 (2%) | 3 (3%) | 0 | 4 |
Abbreviations: LNI=lymph node involvement; LNR=lymph node ratio; PP=pleural-pericardial. Bold values were used to indicate significant variables.