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. 2016 Jun 30;115(3):364–370. doi: 10.1038/bjc.2016.201

Figure 5.

Figure 5

Schematic sketch outlining 12(S)-HETE-triggered signal transduction. 12(S)-HETE is secreted by immune- and cancer cells. Various reports (a selection is listed by 1–10; see citations below) demonstrate the effects, which 12(S)-HETE elicits in endothelial cells (LEC: lymph endothelial cell; BEC: blood endothelial cell), or in PC3 prostate cancer cells. The cascades of signal transducing components that were discovered in these studies are shown. The details connected by black arrows depict the findings of this study. 12-HETER, high-affinity 12(S)-HETE receptor; BLT2, leukotriene B4 receptor 2 – low affinity 12(S)-HETE receptor; VE-cad, VE-cadherin. References: (1) Kim et al, 2008; (2) Rigby et al, 2015; (3) Wen et al, 2008; (4) Kerjaschki et al, 2011; (5) Vonach et al, 2011; (6) Viola et al, 2013; (7) Honn et al, 1994; (8) Uchide et al, 2007; (9) Guo et al, 2011; (10) Bolick et al, 2005.