Table 1.

Protection in BALB/c or C57BL/6J mice immunized with PbΔmrp2 or PbΔb9Δslarp sporozoites

Mouse strain	Parasite line	Immunization dose(s) (sporozoites)	No. protected/no. challenged
BALB/c	PbΔmrp2	1 × 1,200	5/5*
		1 × 800	3/5†
		1 × 400	5/5
	PbΔb9Δslarp	1 × 1,200	6/6‡
		1 × 800	4/5
		1 × 400	5/5
	Naive control	–	0/5
C57BL/6	PbΔmrp2	3 × 10,000	9/10§
		3 × 1,000	0/10‖
		3 × 200	0/10
	PbΔb9Δslarp	3 × 10,000	10/10¶**
		3 × 1,000	3/10
		3 × 200	0/10
	Naive control	–	0/3

^*P = 0.44 (Fisher's exact test) for PbΔmrp2 1 × 1,200 vs. 1 × 800.

^†P = 1 (Fisher's exact test) for PbΔmrp2 1 × 800 vs. PbΔb9Δslarp 1 × 800.

^‡P = 0.45 (Fisher's exact test) for PbΔb9Δslarp 1 × 1,200 vs. 1 × 800.

^§P = 0.0001 (Fisher's exact test) for PbΔmrp2 3 × 10,000 vs. 3 × 1,000 or 3 × 200.

^‖P = 0.21 (Fisher's exact test) for PbΔmrp2 3 × 1,000 vs. PbΔb9Δslarp 3 × 1,000.

^¶P = 0.0031 (Fisher's exact test) for PbΔb9Δslarp 3 × 10,000 vs. 3 × 1,000.

^**P < 0.0001 (Fisher's exact test) for PbΔb9Δslarp 3 × 10,000 vs. 3 × 200.