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. 2016 Aug 4;6:30957. doi: 10.1038/srep30957

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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SEA upregulates the expression of P-STAT3 via the activation of TLR4 signaling. Then, P-STAT3 may contribute to the upregulation of P-p53 as well as its targeting gene, p21. Additionally, SOCS3 is also involved in the process through interaction with p53. Ultimately, the increased level of p21 promotes the senescence of LX-2 cells.