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. 2016 Aug 4;6:31070. doi: 10.1038/srep31070

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Cultured cortical neurons derived from PICK1 WT and knockout (KO) mice and transfected with empty pSuper vector (control) or pSuper-PACSIN1-shRNA#1 were subjected to the pH-GluA2 recycling assay. (a) Average time course of pH-GluA2 fluorescence changes (ΔF/F_o) in neurons. Quantification of the amplitude of the pH-GluA2 fluorescence change in response to NMDA stimulation (b) and its recycling rate (t_1/2) after NMDA washout (d). Data represent mean ± s.e.m. (One-way ANOVA, *P < 0.05, **P < 0.01, n = 7 (PICK1-WT/pSuper), 7 (PICK1-WT/sh#1), 6 (PICK1-KO/pSuper), 6 (PICK1-KO/sh#1) neurons from 3 independent cultures).