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. 2016 Aug 4;6:30743. doi: 10.1038/srep30743

Figure 1. GluN2B is required for the acquisition of contextual fear memory in the CA1 region, but its requirement for memory consolidation depends on conditioning strength.

Figure 1

Hippocampal injections of the GluN2B-selective antagonist ifenprodil (ifen) before fear conditioning impaired 1-h short-term memory elicited by a single conditioning trial (1 CS-US). (B,C) Hippocampal injections of ifenprodil before (B) or immediately after (C) fear conditioning had no effect on 48-h long-term memory elicited by 1 CS-US. (D) Hippocampal injections of ifenprodil before fear conditioning impaired 1-h short-term memory elicited by five conditioning trials (5 CS-US). (E,F) Hippocampal injections of ifenprodil before (E) or immediately after (F) fear conditioning impaired 48-h long-term memory elicited by 5 CS-US. Top panels indicate the design of the experiments in A–F. **p < 0.01.