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. 2016 Aug 4;6:31041. doi: 10.1038/srep31041

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Copyright © 2016, The Author(s)

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(a) Sensorgrams measured using a quartz microbalance with immobilized GroEL-AD and varying concentrations of soluble α-synuclein. The molar concentration of α-Synuclein used for each sensorgram was as follows from top to bottom: 1.72 μM, 3.45 μM, 6.90 μM (green trace), 13.8 μM (red trace). Raw data of each trace were fitted non-linearly to a two phase exponential decay equation to obtain two apparent amplitude values and two rate constants, k_obs^fast and k_obs^slow. The net change in frequency, |ΔF|, was estimated by adding the two derived amplitudes of the analysis. (b) Non-linear fitting of |ΔF| values to the molar concentration of soluble GroEL-AD. See the Materials and Methods section for details on the analysis and the main text for derived K_d values. (c) Linear regression analysis of k_obs^fast against [α-Synuclein]. (d) Linear regression analysis of k_obs^slow against [α-Synuclein]. See main text for details and derived K_d values.