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. 2016 Jul 15;30(14):1636–1644. doi: 10.1101/gad.281972.116

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© 2016 Zhang et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — Lipid metabolic genes up-regulated in both HNF6 knockout (KO) and Rev-erbα knockout mice are enriched for the HNF6-tethered Rev-erbα functional cistrome. (A) GSEA results for the enrichment of genes up-regulated by HNF6 knockout in Rev-erbα knockout livers. (B) GO analysis of the genes up-regulated in both HNF6 knockout and Rev-erbα knockout livers. (C) The number of functional Rev-erbα-binding sites near the genes up-regulated in both Rev-erbα and HNF6 knockout and near the genes that were specifically up-regulated or down-regulated in the HNF6 knockout. (*) P value < 0.0001, hypergeometric test. (D) Significant enriched motifs (P value < 0.0001) in the functional Rev-erbα-binding sites near the genes up-regulated in both Rev-erbα knockout and HNF6 knockout.