Figure 6.

HNF6 knockout decreased Rev-erbα binding tethered by HNF6 but not other tethering factors. (A) Highly enriched motifs found in all Rev-erbα DBD-independent sites. (B) Scatter plots of the Rev-erbα DBD-independent cistrome in the wild-type control (X-axis) and HNF6 knockout (KO) (Y-axis). The down-regulated sites are plotted in green. The cutoff for differentially regulated sites was a fold change of >3. (C) Highly enriched known motifs in down-regulated Rev-erbα-tethered-binding sites. (D) Scatter plots of the Rev-erbα DBD-independent cistrome in the wild-type control (X-axis) and HNF6 knockout (Y-axis). The Rev-erbα-binding sites overlapping with HNF6 are plotted in blue.