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. 2016 Jul 28;7(7):e2308. doi: 10.1038/cddis.2016.115

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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PML-NB integrity and ATM activation. Double immunofluorescence of pSer1981-ATM (Alexa Fluor 488, green fluorophore) and PML (Alexa Fluor 610, red fluorophore) foci performed in cells untreated or irradiated with 1 Gy and fixed after 0.5 and 3 h. Representative images of the analysis performed in (a) APL blasts (cell image: bright field), (b) NB4 cells untreated or treated with 1 μM RA for 72 h previous to IR (counterstain: DAPI), and (c) U937/PR9 cells either untreated or exposed for 8 h to 100 μM ZnSO₄ and then untreated or treated with 1 μM RA for 72 h previous to IR (counterstain: DAPI). Some colocalization signals have been highlighted and marked within the cell by a white square. Confocal microscopy images, magnification × 63; LCS Leica confocal microscope (Leica Microsystems)