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. 2016 Jul 28;7(7):e2311. doi: 10.1038/cddis.2016.219

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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PGA₁ induces cell death in cancer cells. (a) H358 and A549 cells were treated and analyzed in Figure 2a. Levels of cleaved caspase-3 are at the bottom (S.D. <10% average in each case, n=3). (b) A model illustrating the signaling cascades initiated by H-Ras and N- Ras activation after PGA₁ and their roles in apoptosis