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. 2016 Jul 28;7(7):e2315. doi: 10.1038/cddis.2016.228

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The downregulation of TLR-4 in Sjp40-treated LX-2 is associated with cellular senescence. (a) Western blot analysis of the expression levels of P-p53 and TLR-4 in LX-2 cells treated with the Sjp40. Data were expressed as the mean±S.E.M. of three or four independent trials. *P<0.05 compared with the control group; ^&P<0.05 compared with the control group; ^$P<0.05 compared with the Sjp40-treated group. (b) Enhanced expression of TLR-4 by LPS restored the Sjp40-induced senescence analyzed by senescence-associated β-galactosidase assay (original magnification × 200) and the graph also reveals quantitative analysis of the percentage of SA-β-Gal-positive cells (%) expressed as the mean±S.E.M. of three or four independent trials. *P<0.05 compared with the LPS-treated group; **P<0.01 compared with control group. Bar: 50 μm