Figure 5.

Effect of probucol on infarct volumes and neurological deficits following focal cerebral ischemia in normal mice. (A) Representative photographs of coronal brain sections from vehicle- (Veh) and probucol-treated mice stained with 2,3,5-triphenyltetrazolium chloride. C57BL/6J mice received probucol (3, 10, and 30 mg/kg in 1% DMSO, orally) once per day for 4 d prior to the ischemic insults. White indicates the infarct area. (B) Quantification of the infarct volumes 24 h after 1 h of middle cerebral artery occlusion (n=6). The infarct volumes were calculated by integrating the infarct areas in 2 mm-thick coronal slices. (C) Neurological deficits were assessed in each mouse 24 h after the ischemic insults in a blinded fashion (n=6). The values are presented as the mean±SEM. ^*P<0.05 and ^**P<0.01 vs vehicle group (Veh).