Table 2. Physiological parameters.
Control | Vehicle | 0.004% Probucol | 0.02% Probucol | 0.1% Probucol | |
---|---|---|---|---|---|
Body weight (g) | 32.64±1.24 | 35.38±0.68 | 37.67±0.74 | 36.44±0.97 | 33.92±1.65 |
MABP (mmHg) | 110.33±2.04 | 112.32±2.52* | 110.84±2.43 | 113.98±1.64 | 107.10±3.51 |
pH | 7.40±0.01 | 7.43±0.01 | 7.43±0.02 | 7.40±0.01 | 7.39±0.02 |
pO2 (mmHg) | 96.40±2.16 | 96.50±1.38 | 96.43±2.19 | 95.88±1.38 | 96.81±0.86 |
pCO2 (mmHg) | 35.07±1.71 | 32.29±1.29 | 32.33±1.89 | 33.68±1.00 | 36.30±1.67 |
Total cholesterol | 108.17±9.64 | 240.38±21.39** | 292.14±20.26 | 264.75±37.69 | 114.00±32.24# |
LDL-cholesterol | 27.83±2.41 | 153.25±16.81** | 167.86±9.77 | 157.00±32.74 | 59.00±14.67# |
Values are the mean±SEM. Body weight is expressed in grams. MABP (mean arterial blood pressure), pO2, and pCO2 are expressed in mmHg.
*P<0.05,
**P<0.01 vs age-matched ApoE KO without HFD (Control);
#P<0.05 vs age- and diet-matched ApoE KO (Vehicle).