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Mean (+/- SEM) differences in direction changes between Baseline and Day 1, Day 7, Sensitization Test (ST), and MEC/Context Test (M/C) for SHRs that were treated with saline (SHR-SAL; circles), nicotine (SHR-NIC; squares), and pretreated with mecamylamine prior to nicotine (SHR-MEC; downward triangles). ST = Sensitization Test, M/C = MEC/Context Test. *Significant main effect of Drug.
