Table 1. Group assignment and dosing schedule in experiment 2.
Group | Acclimation (PND 99) | Acclimation (PND 100) | Baseline (PND 101) | Chronic NIC (PND 102-108) | Sensitization Test (PND 111) | MEC/Context Test (PND 113) |
---|---|---|---|---|---|---|
WKY-SAL n = 8 |
No Injection | SAL | SAL | SAL:SAL | SAL:NIC | MEC:SAL |
WKY-NIC n = 8 |
No Injection | SAL | SAL | SAL:NIC | SAL:NIC | MEC:SAL |
SHR-SAL n = 7 |
No Injection | SAL | SAL | SAL:SAL | SAL:NIC | MEC:SAL |
SHR-NIC n = 8 |
No Injection | SAL | SAL | SAL:NIC | SAL:NIC | MEC:SAL |
SHR-MEC n = 8 |
No Injection | SAL | SAL | MEC:NIC | SAL:NIC | MEC:SAL |
Note. Cells within each column indicate the drug administered to rats in each phase. Each column is labeled with the corresponding phase and age of the rats during that phase. Cells with two drugs separated with a colon refer to the pretreatment drug administered 20 min prior to testing (to the left of the colon) and the drug administered immediately prior to testing (to the right of the colon). During the Chronic NIC phase, the nicotine dose administered to WKY-NIC, SHR-NIC, and SHR-MEC was 0.6 mg/kg, s.c. On Sensitization Test day all rats received a nicotine dose of 0.3 mg/kg, s.c.