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. Author manuscript; available in PMC: 2016 Aug 4.
Published in final edited form as: J Immunol. 2016 Apr 29;196(11):4622–4631. doi: 10.4049/jimmunol.1502452

Figure 1. Ccr5 is critical for survival and viral clearance in the CNS during LGTV infection.

Figure 1

(A) Kaplan-Meier survival analysis of LGTV-infected WT (black circles) and Ccr5−/− (grey squares) mice. (B) Body weight was measured for LGTV-infected WT and Ccr5−/− mice. All data shown (A–B) are pooled from three independent experiments (31 WT mice and 32 Ccr5−/− mice). Viral titers were quantified in (C) the blood and (D) spleen by qRT-PCR, and in (E) the brain and (F) spinal cord by FFU assay. Dotted lines indicate the limit of detection. All data (C–F) are shown as mean ± SD for 3–8 mice per genotype and time point from two independent experiments. * p<0.05 and *** p<0.001.