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Loss of CREB and CREM impairs the proliferation of striatal precursors. (A–B) Quantitative analysis of total cells in high (A) and clonal (B) density neurosphere cultures established from dissociated GE of E13.5 embryos with the indicated genotypes. Data represent means ± SEM in at least 3 independent experiments. Asterisks indicate significant differences versus control (Ctr; ANOVA) * P <0 .05; ** P<0 .01. (C) Representative images illustrating clone size and morphology.
