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. 2014 Nov 26;1(1):e970883. doi: 10.4161/23262125.2014.970883

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© 2014 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 6. — Ablation of CREB and CREM results in decreased histone acetylation in the E13.5 telencephalon. (A) Western blot analysis of GE (left column panels) and cortical protein extracts (right column panels) showing analysis of αlpha-tubulin, total histone H2B, acetylated histones H3 and H4. (B) Quantification of western blot analysis of the GE (Ba and Bb) and cortex (Bc and Bd). Bands were normalized against H2B (Ba and Bc) and α Tubulin (Bb and Bd). Note that ablation of CREB leads to a stronger alteration of histone acetylation in the GE (Ba and Bb) than in the cortex (Bc and Bd). Asterisks indicate significantly different from the respective control (Ctr) (ANOVA) * P < 0.05; **P < 0.01.