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. 2014 Nov 17;1(1):e976026. doi: 10.4161/23262133.2014.976026

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© 2014 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 5. — Schematic representation of the expression pattern of Np95 in embryonic brain and adult hippocampal DG. (A) NS/PCs acquire the pluripotency to differentiate into neurons, astrocytes and oligodendrocytes during embryonic development. Np95 is specifically expressed in NS/PCs and not expressed in their completely differentiated neural cell progeny. (B) Schematic diagram illustrating the current view of lineage relationships and marker expression during adult hippocampal neurogenesis. Adult hippocampal neurogenesis occurs in 5 stages: [1] activation of quiescent radial glia-like cells (type 1 (change of morphology from radial to horizontal)) in the SGZ; [2] proliferation of precursor and intermediate progenitors (type 2a, 2b, transit-amplifying cells); [3] generation of neuroblasts (type 3); [4] differentiation into immature neurons; [5] maturation of immature neurons. Np95 is preferentially expressed in type 2a transit-amplifying NS/PCs. Circular arrows indicate the frequency of cell division. Solid arrows show frequently dividing cells compared with dashed arrows. ML: molecular layer; GCL: granule cell layer; SGZ: subgranular zone.