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. 2015 Sep 21;2(1):e1057313. doi: 10.1080/23262133.2015.1057313

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© 2015 The Author(s). Published with license by Taylor & Francis

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 7. — spry4 shows a bivalent response to changes in Wnt and FGF signaling. Polynomials were fitted against the spatial expression of spry4 in the dorsal midbrain (µm) at 16.5, 18, 20 hpf following treatment with IWR-1 from 14 hpf (A) and showed a good fit (R² = 0.7201, n = 10 for each condition). A line plot of the spry4 expression domain (scaled to midbrain size) in the same embryos (B) reveals that treatment with 20µM IWR-1 had the strongest affect (n = 10 for each condition). Lateral views of 20 hpf embryos processed by in situ hybridization to reveal spry4 (blue) and pax6 (red) expression following treatment from 14 hpf with DMSO (C), 20µM IWR-1 (D), 30µM IWR-1 (E), 10µM SU5402 (F), 20µM IWR-1 with 10µM SU5402 (G), or 30µM IWR-1 with 10µM SU5402 (H). Isthmus (i). Scale bars: 100µm (C–H).