Table 1.

Summary of gene expression changes in the midbrain at 24 hpf due to alterations of Wnt or FGF activity from 14 hpf (SU5402, IWR-1, BIO) or 16.5 hpf (dkk1, βummar

Signaling pathway manipulation			gene expression in the midbrain
Wnt	FGF	treatment	lef1	wnt1	pea3	her5	spry4	fgf8
↑		BIO	↑	↓	↓	↓	↑	↑
↑		bcat	↑	↑	↓	↓	↑	↓
↓		dkk1	↓		↓	↓	↓
↓		IWR-1	↓	↑		↓
	↑	CA-fgfr1	↑	↑	↑		↑	↓
	↓	SU5402	↓	↓	↓	↓	↓	↓
↑	↓	BIO + SU5402	↑	↓	↓	↓	↑	↑
↑	↓	bcat + SU5402	↑	↓	↓	↓
↓	↓	IWR-1 + SU5402	↓	↓	↓	↓	↓
reduced expression relative to control
no change relative to control
elevated expression relative to control