Table 3.

Results from generalized linear models describing expression of her5 (scaled relative to midbrain size) as i) a function of SU5402 at 10µM (fSU540210) and IWR-1 at either 20 or 30µM (fIWR120, fIWR130), or ii) a function of SU5402 at 10µM relative to IWR-1 (fIWR1). Addition of IWR-1 at 20 or 30µM does not result in significant changes to her5 expression (p > 0.05), but SU5402 does (p < 0.001). Addition of 30µM IWR-1 in the presence of SU5402 has an affect on her5 expression with low significance (p < 0.1), but overall IWR-1 does not significantly alter the response of her5 to SU5402 (p = 0.076). Fit of data to models R² = 0.67

i) her5 expression as a function of IWR-1 and SU5402 concentration.

	Estimate Std.	Error	t value	Pr(>|t|)
(Intercept)	0.48836	0.02693	18.136	< 2e-16 ***
fIWR120	0.03078	0.03942	0.781	0.440123
fIWR130	0.03709	0.04113	0.902	0.373348
fSU540210	−0.14845	0.03808	−3.898	0.000418 ***
fIWR120:fSU540210	−0.05031	0.05697	−0.883	0.383250
fIWR130:fSU540210	−0.10557	0.05817	−1.815	0.078133.
ii) her5 expression as a function of IWR-1 and SU5402 presence.
	Estimate Std.	Error	t value	Pr(>|t|)
(Intercept)	0.489451	0.025566	19.145	< 2e-16***
fSU540210	−0.145272	0.036210	−4.012	0.000282***
IWR1	0.001297	0.001294	1.003	0.322598
fSU540210:IWR1	−0.003342	0.001833	−1.823	0.076349.