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. Author manuscript; available in PMC: 2016 Aug 4.

Published in final edited form as: Support Care Cancer. 2014 Oct 24;23(5):1311–1319. doi: 10.1007/s00520-014-2465-z

Mean differences in pain scores are shown for each extremity in the AM: A) stressed and rested feet and B) stressed and rested hands. Each bar represents one individual. The average of the difference was calculated across the first 40 days on protocol. Difference in pain score was defined as placebo minus active score; thus, efficacy of the treatment is reflected by a positive difference.

Mean differences in pain scores are shown for each extremity in the AM: A) stressed and rested feet and B) stressed and rested hands. Each bar represents one individual. The average of the difference was calculated across the first 40 days on protocol. Difference in pain score was defined as placebo minus active score; thus, efficacy of the treatment is reflected by a positive difference.