Formation of abdominal aortic aneurysm in Apoe−/−/Cyp1b1+/+ mice infused with angiotensin (Ang) II for 28 days is alleviated by treatment with 2,3′,4,5′-tetramethoxystilbene (TMS) but not by its vehicle (Veh) dimethyl sulfoxide or by Cyp1b1 gene disruption. A and B: Quantitated data for the ultrasound B-mode images in short axis (A, Figure 1A), and corresponding quantified data (B) for ex vivo measurements of aortic diameter by Vernier caliper. C: Representative ultrasound B-mode image of aorta in the long axis. n = 5 for each group. ∗P < 0.05, ∗∗∗P < 0.001 (two-way analysis of variance followed by the Bonferroni multiple-comparisons test).