Table 3.

Macrophage Populations Present in the Uninfected Spleen

Variable	Germinal center	Mantle zone	Marginal zone	Red pulp
CD68	2.3 ± 0.2	1.1 ± 0.1	1.8 ± 0.1	1.3 ± 0.3
CD163	0 ± 0	0.1 ± 0.1	1.3 ± 0.2	1.0 ± 0.3
CD68/CD163	0.3 ± 0.2	0.1 ± 0.1	2.1 ± 0.3	3.0 ± 0
Mac387	0 ± 0	1.0 ± 0.2	2.2 ± 0.2	1.4 ± 0.2

To quantitate the presence of each macrophage subset in seven uninfected macaques, three random fields were analyzed and numerical scores of 0, 1, 2, or 3 were assigned. In this scoring system, 0 represented an absence of the macrophage population, 1 indicated a minimal presence (1 ≤ 20 cells), 2 indicated a moderate presence of the macrophages (20 to 100 cells), and 3 indicated the presence of many macrophages in spleen (≥ 100 cells). Data are expressed as means ± SD. Bold text indicates the predominant macrophage subset(s) within each area of spleen.