Skip to main content
. 2016 Jul 29;11:3571–3583. doi: 10.2147/IJN.S110406

Figure 4.

Figure 4

Cub-PS eliciting strong antigen-specific antibody and antibody subclass responses in vivo.

Notes: (A) Antigen-specific IgG levels in the serum on injection of different contents of Cub-PS after first immunization. (B) Antigen-specific IgG levels in the serum at the indicated time points after first immunization. (C) IgG1 and IgG2a levels in the serum of immunized mice 21 days after the first immunization. (D) IgG2b and IgG3 levels in the serum of immunized mice 21 days after the first immunization. Data are expressed as the mean ± SEM. *P<0.05 and **P<0.01 vs the PS-Ag group; #P<0.05 and ##P<0.01 vs the Cub-Ag group.

Abbreviations: Ag, antigen; Cub-Ag, mixture of cubosomes and Ag; Cub-PS-Ag, mixture of cubosome-polysaccharide nanoparticles and Ag; Ig, immunoglobulin; OD, optical density; PS-Ag, mixture of PS and Ag; SEM, standard error of the mean.