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Differential DNA methylation patterns in prokaryotes, lower eukaryotes, and higher eukaryotes. (A) Pictorial representation of cytosine, 5-methylcytosine, 5-hydroxymethylcytosine, and N6-methyladenine; (B) prokaryote, (C) lower eukaryote, and (D) higher eukaryote DNA methylation is denoted in red on either adenine (A) or cytosine (C).
