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Differential methylation of H4R in the maternal oocyte regulates the methylation status of DNA during embryogenesis. (A) No maternal oocyte H4R3 methylation yields little DNA CpG site methylation. (B) Maternal oocyte H4R3 methylation yields more methylation of DNA CpG sites. Red indicates methylation and empty circles represent nonmethylation. DNMT3a denotes DNA methyltransferase 3a.
