Table 2.
FIT Performance Characteristics at Each Round of Screening and Overall*
| Variable | Round 1 | Round 2 | Round 3 | Round 4 | Total |
|---|---|---|---|---|---|
| FIT participation | |||||
|
| |||||
| KPNC | 179 423/348 510 (51.5) | 104 255/133 652 (78.0) | 93 999/111 190 (84.5) | 85 695/96 634 (88.7) | 463 372/689 986 (67.2) |
|
| |||||
| KPSC | 143 926/322 331 (44.7) | 79 733/110 824 (71.9) | 69 282/84 503 (82.0) | 59 757/72 219 (82.7) | 352 698/589 877 (59.8) |
|
| |||||
| Total | 323 349/670 841 (48.2) | 183 988/244 476 (75.3) | 163 281/195 693 (83.4) | 145 452/168 853 (86.1) | 816 070/1 279 863 (63.8) |
|
| |||||
| FIT positivity | |||||
| KPNC | 8495/179 423 (4.7) | 3781/104 255 (3.6) | 3303/93 999 (3.5) | 3507/85 695 (4.1) | 19 086/463 372 (4.1) |
|
| |||||
| KPSC | 7542/143 926 (5.2) | 3362/79 733 (4.2) | 2799/69 282 (4.0) | 2704/59 757 (4.5) | 16 407/352 698 (4.7) |
|
| |||||
| Total | 16 037/323 349 (5.0) | 7143/183 988 (3.9) | 6102/163 281 (3.7) | 6211/145 452 (4.3) | 35 493/816 070 (4.3) |
| Follow-up colonoscopy | |||||
|
| |||||
| KPNC | 6396/8495 (75.3) | 2962/3781 (78.3) | 2657/3303 (80.4) | 2880/3507 (82.1) | 14 895/19 086 (78.0) |
|
| |||||
| KPSC | 5717/7542 (75.8) | 2785/3362 (82.8) | 2255/2799 (80.6) | 2159/2704 (79.8) | 12 916/16 407 (78.7) |
|
| |||||
| Total | 12 113/16 037 (75.5) | 5747/7143 (80.5) | 4912/6102 (80.5) | 5039/6211 (81.1) | 27 811/35 493 (78.4) |
|
| |||||
| PPV | |||||
| Adenoma for KPNC | 3297/6396 (51.5) | 1403/2962 (47.4) | 1288/2657 (48.5) | 1380/2880 (47.9) | 7368/14 895 (50.1) |
|
| |||||
| Advanced adenoma† for KPNC | 895/6396 (14.0) | 295/2962 (10.0) | 265/2657 (10.0) | 243/2880 (8.4) | 1698/14 895 (11.4) |
|
| |||||
| CRC | |||||
| KPNC | 322/8495 (3.8) | 84/3781 (2.2) | 75/3303 (2.3) | 71/3507 (2.0) | 552/19 086 (2.9) |
|
| |||||
| KPSC | 223/7542 (3.0) | 63/3362 (1.9) | 63/2799 (2.3) | 57/2704 (2.1) | 406/16 407 (2.5) |
|
| |||||
| Total | 545/16 037 (3.4) | 147/7143 (2.1) | 138/6102 (2.3) | 128/6211 (2.1) | 958/35 493 (2.7) |
CRC = colorectal cancer; FIT = fecal immunochemical test; KPNC = Kaiser Permanente Northern California; KPSC = Kaiser Permanente Southern California; PPV = positive predictive value.
*
Values are numbers/totals (percentages).
†
Adenomas with villous or tubulovillous histologic characteristics.