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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Neurobiol Aging. 2016 Mar 8;42:80–90. doi: 10.1016/j.neurobiolaging.2016.02.031

Figure 3. Select protein homeostasis genes are dysregulated in pS422+ NBM neurons as compared to unlabeled, tau pathology-negative NBM neurons.

Figure 3

Heatmap of expression levels of transcripts mediating protein homeostasis in NBM neurons (red to green = increasing mRNA levels). Quantitative analysis revealed that 7 of 16 genes involved in protein homeostasis were significant upregulated in pS422+ neurons as compared to unlabeled control neurons. One gene, ppp2r1a protein phosphatase 2 regulatory subunit was significantly downregulated. These alterations could indicate early mechanistic changes preceding NBM neurofibrillary degeneration. The appearance of the tau neoepitope TauC3 revealed upregulation of 5 additional transcripts. a, (pS422+, pS422+/tauC3+, tauC3+) > unlabeled, p < 0.01; b, (pS422+/tauC3+, tauC3+) > (unlabeled, pS422+), p < 0.01; c, (pS422+/tauC3+, tauC3+) > (unlabeled, pS422+), p < 0.05; d, unlabeled > pS422+ > (pS422+/tauC3+, tauC3+), p < 0.01. Abbreviations are as defined in Fig. 2.