Table 1. Half-maximal rate times (t½) of L-glutamine action on several metabolic fluxes.
| Metabolic fluxes | t½ (minutes) | ||
|---|---|---|---|
| Control | Type 1 diabetes | Type 2 diabetes | |
| Glucose production | 32.68±1.89 (n = 11) | 19.83±1.53* (n = 12) | 29.99±1.30 (n = 12) |
| Ammonia production | 26.91±2.45 (n = 6) | 14.12±2.42* (n = 7) | 23.47±0.78 (n = 6) |
| Urea production | 31.52±3.02 (n = 6) | 16.16±3.69* (n = 6) | 23.80±0.95* (n = 6) |
| Lactate production | 43.23±3.94 (n = 6) | 16.65±3.74* (n = 6) | 34.90±2.23 (n = 5) |
| Oxygen uptake | 28.95±1.82(n = 11) | 19.01±1.55* (n = 12) | 27.38±1.46 (n = 12) |
The t½ values are expressed in terms of time after initiation of L-glutamine infusion and were obtained by numerical interpolation (Stineman's interpolation) within each individual glutamine response curve of the experimental series illustrated by Figs 1 and 2. Data are means ± SEM and asterisks are used to indicate values differing statistically from the corresponding controls according to the Student-Newman-Keuls test applied after monovariate variance analysis (p ≤ 0.05).