Fig 3. Increased tumor predisposition in Brca2^G25R hemizygous mice.

A. Median and average age of death, including number of mice per genotype analyzed (n) and shown by gender. B. Kaplan-Meier tumor-free survival curves of Brca2 mutant animals (104 week study). C. Kaplan-Meier tumor-free survival curves of Brca2 mutant mice on a Trp53^Ko/+ genetic background (104 week study). D. and E. Distribution of tumor types found in mice of indicated genotypes. Abbreviations: NT = No tumor observed, BCL = B-cell lymphoma, TCL = T-cell lymphoma, HS = Histiocytic sarcoma, OS = Osteosarcoma, HemS = Hemangiosarcoma, OthSa = Other sarcomas, AD = Adenomas, OthCa = Other carcinomas, MT = Multiple tumors, UNK = cause of death unknown. * UNK are included in the tumor-free survival curves as potential neoplasias. Controls are represented by: Brca2^+/+ and Brca2^Ko/+. Abbreviations: Brca2^Ko/+ = B2^Ko/+, Brca2^G25R/+ = B2^GR/+, Brca2^G25R/G25R = B2^GR/GR, Brca2^G25R/Ko = B2^GR/Ko.