Fig 2. Ingenuity biological function analysis of DEG associated with 1 dose of DOX-based chemotherapy in patients with abnormal decline of LVEF at completion of chemotherapy.

The most enriched “biological functions” of this dataset identified using Ingenuity software were “cell-to-cell signaling” (p-value = 1.40E-07–3.2E-02), “cellular movement” (p value = 2.23E-04–2.02E-02) and “cellular development” (p value = 2.85E-04–2.89E-03). The most represented “diseases and disorders” were “connective tissue disorders” (p value 2.53E-12–2.57E-02), “inflammatory diseases” (p value = 2.53E-12–3.13E-02), “skeletal and muscular disorders” (2.53E-12–1.23E-02) and “immunological diseases” (p value = 5.59E-12–3.12E-02).