Table A5:
Studies Included in 2015 Systematic Review by Drekonja et al
| Author, Year | Study Design and Methods | N | Average Patient Age (Years) | Number of CDI Recurrences, N (Range) | Number of Donors and Relationship to Fecal Donor | Reported Length of Follow-Up (Range) | Resolution of Symptoms after FMT, n/N (%) |
|---|---|---|---|---|---|---|---|
| Recurrent CDI; FMT via upper GI tract (7 studies; n = 214 patients [187 patients received FMT]) | |||||||
| Youngster et al, 201451 | Prospective case series | 16 | 60 | 2 (1–5) | 4; not related | 6 months | 13/16 (81) |
| Youngster et al 201418 | RCT | 10 | 55 (among 20 enrolled) | 4.5 (2.0–16.0) | 5; not related | 6 months | 6/10 (60) |
| Van Nood et al, 201317 | RCT | 43 (16 FMT) | 70 (among 43 enrolled) | 3 (1–5) FMT group | 15; NR | 10 weeks | 13/16 (81) |
| Rubin et al, 201352 | Retrospective case series | 74 (72 adults) | 63 (median) | NR | NR; healthy close household member | 60 days | 58/72 (81) |
| Garborg et al, 201053 | Retrospective case series | 40 | 75 | NR | NR; close relative or other household member | 80 days | 29/40 (73) |
| MacConnachie et al, 200920 | Retrospective case series | 15 | 82 | 4 (3–7) | NR; related | 16 weeks (4–24 weeks) | 11/15 (73) |
| Aas et al, 200321 | Retrospective case series | 18 | 73 | 3.6 (2.0–7.0) | 16; spouse, partner, household family member | 90 days | 15/18 (83) |
| Recurrent CDI; FMT via colonoscopy (11 studies; n = 257) | |||||||
| Khan et al, 201454 | Retrospective case series | 20 | 66 | 5.1 | 20; spouse, partner, first-degree relative, not related | 6 months | 18/20 (90) |
| Youngster et al, 201418 | RCT | 10 | 55 (among 20 enrolled) | 4.5 (2.0–16.0) | 5; not related | 6 months | 8/10 (80) |
| Cammarota et al, 201455 | Retrospective case series | 3 | 67 | 1–5 | 3; child sibling, not specified | 4–5 months | 3/3 (100) |
| Pathak et al, 201356 | Retrospective case series | 12 (11 via colonoscopy) | 72 | NR | 12; spouse, child sibling, niece | 2–29 months | 11/12 (92) |
| Patel et al, 201319 | Retrospective case series | 31 | 61 | 4 (2–7) | 33; spouse, child sibling, parent, niece, friend | 1 week–1 year | 22/30 (73) |
| Hamilton et al, 201257 | Retrospective case series | 43 | 59 | 5.9 | 12; parent, child, spouse, friend, volunteer | 2 months | 37/43 (86) |
| Kelly et al, 201258 | Retrospective case series | 26 | 59 | ≥ 3 | 26; partner, sibling, spouse, child, cousin, friend | 11 months (2–30 months) | 25/26 (96) |
| Mattila et al, 201259 | Retrospective case series | 70 | 73 | 3.5 (1.0–12.0) | 62; relative or household contact, volunteer | 12 months | 66/70 (94) |
| Mellow and Kanatzar, 201160 | Retrospective case series | 13 (12 recurrent) | 67 | 4 (3–7) | NR; chosen by patient | 5 months (1–10 months) | 11/12 (92) |
| Rohlke et al, 201061 | Retrospective case series | 19 | 49 | NR | 19; partner, family member, housemate | 27 months (6 months–5 years) | 18/19 (95) |
| Yoon and Brandt, 201062 | Retrospective case series | 12 | 66 | NR | 12; spouse, partner, child/grandchild | 3 weeks–8 years | 12/12 (100) |
| Recurrent CDI; FMT via enema (5 studies; n = 45) | |||||||
| Emanuelsson et al, 201463 | Retrospective case series | 23 | 67 | 3 (1–5) | NR; spouse or close relative | 18 months (birth-courses of antibiotics 21 months) | 15/23 (65) |
| Silverman et al, 201064 | Retrospective case series | 7 | 72 | NR | 7; child/grandchild, spouse, sibling | 8.6 months (4–14 months) | 7/7 (100) |
| Gustafsson et al, 199965 | Retrospective case series | 6 | 61 | NR | 1; not related | 18 months | 5/6 (83) |
| Paterson et al, 199466 | Retrospective case series | 7 | 56 | 3 (1–4) | NR; relative | NR | 7/7 (100) |
| Tvede and Rask-Madsen, 198967 | Retrospective case series | 2 | 60 | 3 (2–4) | 2; spouse, child | 12 months | 1/2 (50) |
| Recurrent CDI; FMT via upper GI tract and colonoscopy (1 study; n = 27) | |||||||
| Dutta et al, 201468 | Prospective case series | 27 | 65 | 4.6 (3.0–5.0) | 27; spouse, child, parent | 21 months (10–34 months) | 27/27 (100) |
| Refractory CDI; FMT via upper GI tract (2 studies; n = 12) | |||||||
| Youngster et al, 201451 | Prospective case series | 4 | 72 | 3 (1–5) | 3; not related | 6 months | 1/4 (25) |
| Zainah et al, 201569 | Retrospective case series | 8 | 74 | 3.3 (2.0–5.0) | NR; family member or unrelated | 100 days | 8/8 (100) |
| Refractory CDI; FMT via colonoscopy (2 studies; n = 5) | |||||||
| Weingarden et al, 201370 | Retrospective case series | 4 | 73 | NR | 1; not related | Up to 12 months | 0/4 (0) |
| Mellow and Kanatzar, 201160 | Retrospective case series | 1 (from series) | NR | 1 | 1; chosen by patient | 9 months | 1/1 (100) |
| Refractory CDI; FMT via enema (3 studies; n = 112) | |||||||
| Lee et al, 201471 | Retrospective case series | 94 | 72 | 2.1 (courses of antibiotics) | NR; not related | 6–24 months | 45/94 (48) |
| Bowden et al, 198172 | Retrospective case series | 16 (15 adults) | 59 | NR | NR; household relative, volunteer | NR | 13/15 (87) |
| Eiseman et al, 195873 | Retrospective case series | 3 (patients 1, 2, and 4) | 52 | NR | NR; NR | 2–10 days | 3/3 (100) |
| Initial therapy for CDI; FMT via upper GI tract (1 study; n = 6) | |||||||
| Zainah et al, 201569 | Retrospective case series | 6 | 72 | 0 | NR; family member or unrelated | 100 days | 1/6 (17) |
| Initial therapy for CDI; FMT via enema (1 study; n = 1) | |||||||
| Eiseman et al, 195873 | Retrospective case series | 1 (patient 3) | 68 | NR | NR; NR | 5 days | 1/1 (100) |
Abbreviations: CDI, Clostridium difficile infection; FMT, fecal microbiota therapy; GI, gastrointestinal; NR, not reported; RCT, randomized controlled trial.
Source: Adapted from Drekonja et al.3