Table 3. Gene Ontology(GO) analyses related to CVS T18 DMCs.

Table 3 A	Molecular functions
GO Term	Description	FDR q-value	Enrichment	Genes within GO-term	Tri18 genes within GO-term
GO:0043565	sequence-specific DNA binding	2.50E-11	5.86	743	29
GO:0003677	DNA binding	2.14E-10	3.07	2346	48
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	1.27E-06	6.52	392	17
GO:0003700	sequence-specific DNA binding transcription factor activity	3.47E-06	3.77	1037	26
GO:0001071	nucleic acid binding transcription factor activity	2.83E-06	3.76	1038	26
GO:0003676	nucleic acid binding	4.86E-06	2.11	3770	53
GO:0044212	transcription regulatory region DNA binding	3.40E-05	4.93	518	17
GO:0000975	regulatory region DNA binding	3.61E-05	4.86	525	17
GO:0001067	regulatory region nucleic acid binding	3.21E-05	4.86	525	17
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	4.12E-05	8.22	201	11
Table 3 B	Biological processes
GO Term	Description	FDR q-value	Enrichment	Genes within GO-term	Tri18 genes within GO-term
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.37E-07	4.71	861	27
GO:1903508	positive regulation of nucleic acid-templated transcription	5.72E-07	3.72	1170	29
GO:0019219	regulation of nucleobase-containing compound metabolic process	6.15E-07	2.12	4105	58
GO:0048518	positive regulation of biological process	6.22E-07	2.03	4585	62
GO:0045893	positive regulation of transcription, DNA-templated	6.35E-07	3.72	1170	29
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6.51E-07	2.96	1880	37
GO:0006357	regulation of transcription from RNA polymerase II promoter	6.63E-07	3.33	1487	33
GO:0006355	regulation of transcription, DNA-templated	6.79E-07	2.34	3216	50
GO:0051252	regulation of RNA metabolic process	6.91E-07	2.29	3340	51
GO:1903506	regulation of nucleic acid-templated transcription	6.99E-07	2.32	3240	50
GO:0051173	positive regulation of nitrogen compound metabolic process	7.01E-07	2.91	1907	37

A: Gene functions related to terms within the group “Molecular functions”. B. Gene functions related to terms within the group “Biological processes”. The table shows the enrichment analysis for the genes associated to our DMCs in T18 samples. The total number of genes within the GO analysis is 17727. Our gene set related to the CVS T18 DMCs were 118. Each table shows the 10 GO terms with the lowest False Discovery Rate (FDR q value).