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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Cell Mol Bioeng. 2016 Feb 3;9(2):207–216. doi: 10.1007/s12195-016-0432-0

Figure 3. Working model of torsinA-mediated LINC complex regulation.

Figure 3

A) The two hypothesized steps of LINC complex assembly that may be regulated by torsinA within the perinuclear space are 1) homotrimerization of SUN proteins, and 2) heterohexamerization of KASH-SUN proteins. SUN proteins form homotrimers in the absence of KASH proteins12, 13, 83. While torsinA may positively and/or negatively regulate one or both of these steps, the precise regulatory mechanism remains unclear.