TABLE I.

Dana–Farber Cancer Institute protocol for adult acute lymphoblastic leukemia, intensification phase

Age group	Drug	Dose and route	Schedule
Age < 60 years (30 weeks, 21 days per cycle)
Dexamethasone		Oral, 9 mg/m2	Twice daily, days 1–5
Vincristinea		Intravenous, 2 mg	Day 1
Doxorubicin		Intravenous, 30 mg/m2	Day 1, cycles 1–7
6-Mercaptopurine		Oral, 50 mg/m2	Days 1–14
Asparaginase		Intramuscular, 12,500 IU/m2	Days 1, 8, and 15
Methotrexate		Intravenous, 30 mg/ m2	Days 2, 9, and 16; cycles 8–10
Cytarabine–methotrexate–hydrocortisone		Intrathecal, 40 mg–12 mg–15 mg	Every 18 weeks
Age ≥ 60 years (21 weeks, 21 days per cycle)
Dexamethasone		Oral, 6 mg	Twice daily, days 1–5
Vincristinea		Intravenous, 2 mg	Day 1
Doxorubicin		Intravenous, 30 mg/m2	Day 1
6-Mercaptopurine		Oral, 50 mg/m2	Days 1–14
Asparaginase		Intramuscular, 6000 IU/m2	Days 1, 8, and 15
Cytarabine–methotrexate–hydrocortisone		Intrathecal, 40 mg–12 mg–15 mg	Every 18 weeks

^aFor patients with grade III or IV neuropathy, substitute intravenous vinblastine 10 mg.