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. 2016 Jul 28;99(2):443–450. doi: 10.1016/j.ajhg.2016.06.010

Figure 2.

Figure 2

NBMELs and HUVECs Expressing Mutant GNA14 and GNA11 Demonstrate Morphological Changes

(A) 40× magnification of NBMELs with GNA11 p.Arg183Cys or GNA14 p.Arg179Cys and GNA11 p.Gln209Pro or GNA14 p.Gln205Leu demonstrate elongation and black foci. Melanocytes with GNA11 p.Arg183Cys or GNA14 p.Arg179Cys are more spindled and dispersed than those with GNA11 p.Gln209Pro or GNA14 p.Gln205Leu, which exhibit significant piling.

(B) HUVECs with activating mutations in GNA14 and GNA11 lose the normal cobblestone morphology seen in wild-type cells and exhibit elongation and disarray.